The pathophysiological hallmark is monoclonal immunoglobulin M (IgM) production by a malignant lymphoplasmacytic clone that resides in the bone marrow.ĭiagnosis is most often made following an incidental finding of an IgM paraprotein on a blood test.Īnaemia (due to marrow infiltration), fatigue, and anorexia are the most common clinical features. Waldenström's macroglobulinaemia (WM) is a rare indolent B-cell lymphoma that most commonly occurs in older white men.
